Adaptogens and The Nervous System

If you’ve been feeling wired but tired lately, adaptogens may be one supportive addition to your routine.

When life feels uncertain (financial pressure, constant headlines, family stress, work overload), the nervous system can get stuck in “on” mode. Your body becomes alert, reactive, and vigilant… even when nothing is happening right now. 

Over time, that state can flatten your energy, disrupt sleep, increase cravings, and make everything feel harder than it should. This is where adaptogens can be useful.

Not as a magic fix, and not as a stimulant. More like a gentle support that helps your body adapt to stress instead of burning through your reserves.

What Adaptogens Are

Adaptogens are a group of herbs that have been traditionally used to help the body handle stress more effectively. 

They may help regulate the body’s stress response systems, especially the HPA axis (hypothalamus–pituitary–adrenal axis), which is the main communication pathway between your brain, hormones, and adrenal response.

When you’re under chronic stress, the HPA axis can become dysregulated. That can show up as:

– difficulty switching off at night

– light, broken sleep

– energy dips and crashes

– anxiety or irritability

– feeling “tired but restless”

– stronger cravings (especially sugar, caffeine, snack foods)

Research on adaptogens has grown a lot in recent years, especially around stress, anxiety, sleep, and fatigue.

Ashwagandha (Withania somnifera): Stress + Cortisol Support.

Ashwagandha is one of the most researched adaptogens for stress. A 2024 meta-analysis found that ashwagandha significantly reduced perceived stress, anxiety, and cortisol compared with placebo in adults. 

Doses in studies commonly ranged from about 125–600 mg/day, usually taken for 30–90 days.

A broader systematic review of adaptogenic plants (including ashwagandha) also reported consistent reductions in cortisol and stress scores in stressed adults.

In plain language: it can be a good option when someone feels tense, over-activated, not sleeping deeply, and running on “stress fuel.”

Rhodiola Rosea and Theanine: Fatigue + Performance Under Pressure

Modern research is also exploring how adaptogens may influence neuroinflammation and oxidative stress pathways (which can be part of the stress-fatigue loop). 

A 2024 mini-review discusses anti-inflammatory effects of commonly used adaptogens like schisandra, rhodiola, eleuthero, and ashwagandha.

In plain language: adaptogens may support stress resilience not only through hormones, but also through the body’s inflammatory “stress chemistry.”

Rhodiola is often used when stress shows up as mental fatigue, low motivation, brain fog, and depleted energy, especially when someone still has to “perform” (work, study, life demands). 

A 2024 clinical evidence review discusses rhodiola’s use in fatigue, mood, and stress-related contexts.

In plain language, it’s often considered more “daytime supportive” for people who feel exhausted but still have to function.

“Multi-herb adaptogen formulas” are being studied. Newer research is also looking at combinations of adaptogens (because traditional systems rarely use a single herb in isolation). 

For example, a 2026 randomised controlled trial looked at formulas containing combinations like rhodiola + holy basil + schisandra, and also full-spectrum ashwagandha, for people with high stress.

In plain language: combinations may support multiple stress pathways at once (energy, mood, sleep, resilience), but quality and dosing matter.

L-theanine isn’t an adaptogen, but it’s a well-researched calming nutrient found in green tea.

A 2024 trial found that 28 days of L-theanine supplementation significantly reduced perceived stress and improved sleep quality in the studied group.

A 2025 systematic review and meta-analysis also evaluated L-theanine’s effects on sleep outcomes across studies.

In plain language: L-theanine is often helpful for people who feel mentally “busy,” tense, or struggle to downshift at night.

A Chinese Medicine Lens

In Chinese medicine, the “wired and tired” state often reflects a mixed pattern:

Qi deficiency (low capacity, low energy, poor resilience) plus Yin deficiency / heat signs (overheating, restlessness, light sleep, red tongue, dryness) sometimes with blood deficiency (poor sleep, dizziness, palpitations, anxiety)

Many well-designed practitioner formulas (including some that are marketed as “adaptogenic”) often combine elements that tonify Qi and nourish Yin,which makes sense clinically when someone is both depleted and over-activated.

That blend is one reason these formulas can feel more “balancing” than a basic stimulant. The most known (and lesser known) adaptogens

Well-known:

  • Ashwagandha
  • Rhodiola
  • Holy Basil (Tulsi)
  • Siberian ginseng (Eleuthero)
  • Less talked about but powerful:
  • Schisandra (often used for endurance, focus, and stress resilience)
  • Reishi mushroom (more calming/grounding for some people)
  • Licorice (only appropriate in certain people and dosing not for everyone)

Can You Get “Adaptogen Support” From Food?

Food won’t replace therapeutic dosing in many cases, but food can absolutely support nervous system resilience.

Supportive options include:

Quality protein (steady blood sugar = steadier mood)

Soups and stews (especially if depleted, anxious, dry, or under-eating)

Medicinal mushrooms in cooking (reishi as tea, shiitake in meals)

Oats, chia, flax (nervous system steadiness and gut support)

Magnesium-rich foods (pumpkin seeds, leafy greens, legumes)

If someone is “wired,” one of the biggest foundations is simply: regular meals + enough protein + enough minerals + enough sleep opportunity. Adaptogens work better when the basics are in place.

Safety Notes 

Adaptogens are usually well tolerated, but they’re not “one-size-fits-all.”

Please get personalised advice if you:

  • are pregnant or breastfeeding
  • have thyroid conditions (some adaptogens can influence thyroid function)
  • are on antidepressants, sedatives, blood pressure medication, or blood sugar medication
  • have autoimmune conditions or complex health histories

And quality matters: dose, extraction type, and formulation make a huge difference.

The Takeaway

In overwhelming times, the goal isn’t to push harder. It’s to help your system regulate, recover, and rebuild resilience, so you can meet life from a steadier place.

Adaptogens can be one part of that. The best results come when they’re paired with:

  • blood sugar stability
  • mineral support
  • sleep protection
  • gentle nervous system practices (breath, walking, sunlight, downshifting routines)

Want help choosing the right one?

If you’re feeling wired, tired, overwhelmed, or you’re not sleeping deeply, I can help you identify what your body is asking for and whether adaptogens (and which ones) are appropriate for you.

Book an appointment and we’ll build a plan that actually matches your nervous system.

Isabel Peace
Isabel Peace smiling in a white shirt by the beach, with ocean waves and a city skyline behind her.
Isabel Peace is an Integrative Health Practitioner with a special interest in metabolic health, emotional and trauma-informed healing, women’s hormonal balance and fertility, and the care of complex, chronic conditions.
 
Her work brings together nutrition, acupuncture, and Chinese herbal medicine with somatic and evidence-based mind–body approaches, including Internal Family Systems (IFS), EMDR, and TIST. Through this integrative and compassionate approach, Isabel supports her patients to regulate their nervous system, improve metabolic flexibility, and restore balance across physical, emotional, and hormonal health.
 
Isabel’s focus is on sustainable, respectful healing, helping people move out of survival patterns and into greater stability, clarity, and long-term wellbeing.
 

Read more information about Isable Peace. Read about Isable’s background from here.